BPC-157 Dosage | The A-Z Guide

bpc-157 dosage

What’s the best BPC-157 dosage for healing injuries as quickly as possible?

​What’s the best method of administering a BPC-157 dose to accelerate recovery from painful injuries?

 

These are the two questions powerlifters, bodybuilders, and elite athletes have been asking ​for the past decade. At least those who know about the ​potential healing powers of BPC-157.

 

BPC-157 has been proven in animal studies to have several regenerative properties.

 

Improving gut health, reducing symptoms of depression, healing problems in the gastrointestinal tract, and much more.

 

But before we talk about BPC-157 dosing, we need to understand exactly what this miracle molecule does and why so many people are starting to care about it.

 

So let’s answer the most important question…what is BPC-157?

Buy BPC-157 from the #1 online Peptides vendor in the world: Peptides Sciences

Buy BPC-157 from the #1 online Peptides vendor in the world: Peptides Sciences

P.S: This is not medical or legal advice. This is strictly for entertainment purposes. We are not doctors – nor lawyers. All information below is presented for use on “test subjects” only. Not for human consumption. Please read my disclaimer.

What is BPC-157?

The “BPC” in BPC-157 stands for “Body Protection Compound”. It is a synthetic pentapdecapeptide, which means it is a peptide consisting of 15 amino acids.

 

It is derived from the naturally occurring BPC and the sequence of amino acids which are most active in the body.


BPC-157 was first discovered in human gastric juice in 1991, and was later isolated to examine its therapeutic properties.


It was initially use to prevent stomach ulcers, but researchers have noticed several uses for the compound.


Namely, it is an excellent wound healer [1]:

“Indicatively, BPC 157 improves the healing of the skin wounds, muscle, tendin, ligament, and bone injuries.

Furthermore, the observed considerable recovery of the skin wound and muscle, tendon, ligament and bone, after severe injury that could be not spontaneously healed may be quite indicative.

These healing processes may suggest that BPC 157 may distinctively affect tissue healing.”

How exactly does BPC-157 work in the body?

It is believed that there are multiple mechanisms through which BPC-157 is able to provide its healing effects.


One of the main mechanisms is through the formation of blood vessels, a process known as angiogenesis.


BPC-157 does so by upregulating vascular endothelial growth factor (VEGF), a protein in the body responsible for stimulating the growth of new blood vessels [2].


It also increases blood flow in the body by increasing the production and release of nitric oxide (NO) in the body [3]. It’s a phenomenal performance-enhancing peptide, but not in the way you think it is.


BPC-157 has a reputation for accelerating the rate of recovery from a wide variety of injuries.


And although it’s not technically considered an illegal substance by international sports organizations, this may change in the very near future.


As there are very few legitimate human studies available on the safety and efficacy of BPC-157, it currently remains as a “grey market” drug.


But what does the science say regarding the health benefits of BPC-157?

BPC-157

Benefits of BPC-157

To be clear, the benefits of BPC-157 are only extrapolations.

The majority of the studies conducted with this compound are done in cell cultures and animals, so what you’re about to see is an educated guess.

BPC-157 May Be Neuroprotective

A comprehensive review done in 2016 examined the connection between gut health and cognitive disorders.

Specifically, researchers found that BPC-157 affected brain function in the following ways [4]:

  • Lowered depression in rats facing chronic and unpredictable stress

  • Inhibited symptoms of alcohol withdrawal and alcohol intoxication

  • Repairs damaged nerve branches within the brain
Most interestingly, BPC-157’s ability to remain stable in human gastric juice is what makes it so potent.

BPC-157 Can Be Useful In Treating Traumatic Brain Injury (TBI)

Extending off the previous benefit, researchers were able to successfully use BPC-157 in mice who had TBI.

In a 2010 research study, BPC-157 treatment was given to mice who had suffered increasingly greater injuries to the head [5].

The group of mice who were given the strongest dose of BPC-157 (at 10 mcg/kg) had the fewest amount of mice who ended up unconscious or dead.

 

Furthermore, the post-injury damage done to the rats 24 hours after administering BPC-157 was significantly lessened.

BPC-157 Improves Gastrointestinal Health

BPC-157 has been found to impact gastrointestinal health in several ways.

It can counteract complications brought about by inflammatory bowel disease (IBD), lower both acute and chronic inflammation within the gut, and reverse short-bowel syndrome following a resection of the intestine [6].

Additionally, BPC-157 can counteract colon damage and inhibit the formation of ulcers.

BPC-157 Helps Reverse The Damage Done By Drug-Induced Toxicity

An unexpected benefit of BPC-157 involves treating the damage and adverse side effects brought about by commonly used drugs.

For instance, nonsteroidal anti-inflammatory drugs (NSAIDs) can be toxic when they are overdosed. The toxic effects often include seizures, respiratory depression, and hypotension.


As early as 2013, scientists have found that BPC-157 can be used to counteract the toxic brought about by NSAIDs [7].


The more fascinating discovery was how there were no reported toxicity events when extremely high doses of BPC-157 were used.


A similar observation was observed in rats who had methamphetamine-induced neurotoxicity, where BPC-157 was able to reduce the degree and severity of the damage done [8].

BPC-157 Has Anti-Inflammatory Properties

A 2009 experiment was done involving rats with periodontitis, a condition where the gums are infected and heavily inflamed.

Rats who were administered BPC-157 did not have their blood circulation negatively affected.

Most importantly, BPC-157 exhibited anti-inflammatory effects while also healing and preserving the gum tissues [9]!

BPC-157 Dosage Guide | What You MUST Know

Before you go searching for the nearest BPC-157 dosage calculator, you should know about the recommended dosing ranges.

If you dose BPC-157 on the basis of the quoted scientific studies, you will notice the standard BPC-157 dose for rats is 10 mcg/kg.

This is believed to translate into 1.6mcg/kg for humans, so a 90 kg man would end up taking 144 mcg once per day [10].

If you were to use some of the doses anecdotally reported by “test subjects” and users on bodybuilding forums, you will find a much different recommendation.

While there is no universal dosing protocol, a common BPC-157 dose is 250 mcg taken twice per day. First dose in the early morning on an empty stomach, and the second dose right before bed. Obviously, a heavier person would likely require a higher daily dose.

Some “test subjects” have informed me of total daily doses as high at 1 mg per day without side effects, but this was done in cases where they were severely injured and in a great deal of pain.

Whatever BPC-157 dosage my research subjects took, they stuck with it for 4-12 weeks until the injury was fully healed.

12 weeks is about as long as you want to continuously dose BPC-157, with a two-four week “break” to allow your body to return to its natural healing process.

While no side effects have been reported from individuals taking much higher doses, your mileage may vary. Allow for anywhere from a few days to a few weeks for the results to become noticeable and tangible.

And make sure you are accurately calculating your BPC-157 dosage using a legitimate peptide calculator [11]!

Before we talk about how BPC-157’s awesome healing power, it is first important to understand the three phases of how the body naturally heals acute injuries [12]:

BPC-157 For Beginners

If this is your very first time using BPC-157, “start low and go up slowly” would be the best way to safely administer the peptide.

BPC-157 is usually most effective when it is injected either intramuscularly (in the muscle) or subcutaneously (in the skin).

Either form of injection will work, but my “test subjects” advise intramuscular injections for best results.

While the scientific research says BPC-157 acts systemically, many reports from “test subjects” insist it acts locally.

This means you will want to inject BPC-157 a few inches away from the site of injury for best results.

Of course, you want to make sure you are following safe practices when injecting BPC-157.

This includes using sterile needles, having high-quality bacteriostatic water to reconstitute the peptide, and storing the solution in the refrigerator when it is not being used.

You also want to ensure you are living a healthy lifestyle in the form of getting enough sleep, using the right supplements and practicing perfect form when exercising.

One final note: I would personally stay away from oral solutions and transdermal patches, as they are not as effective as injections.

BPC-157

BPC-157 For Healing

Before we talk about how BPC-157’s awesome healing power, it is first important to understand the three phases of how the body naturally heals acute injuries [12]:

  • PHASE I: The Inflammatory Phase (Days 1-5)Platelets aggregate and trigger the release of pro-inflammatory mediators. A clot is formed around the site of injury to stop further bleeding from occurring, which is later broken down by cellular compounds known as macrophages.

  • PHASE II: The Proliferative Phase (Days 5-14)Healthy cells are attracted to the site of injury, and the body stimulates angiogenesis to ensure that a sufficient amount of oxygen and nutrients are transported to the site.

  • PHASE III: The Remodeling Phase (Days 14+)The cells that were used to heal the wound are no longer needed. Through a form of cellular death called apoptosis, they are removed and a scar with properties resembling the original tissue is formed.
With this understanding in mind, let’s examine the types of injuries BPC-157 can heal:
  • A BPC-157 cream was able to heal burn wounds in injured mice [13]

  • In rats, BPC-147 can successfully heal skeletal muscle injuries and restore full functionality to the muscles being healed [14]

  • BPC-157 has the potential to heal spinal cord injury in rats, in which consistent clinical improvements are observed and spinal function is restored [15]

  • BPC-157 can also accelerate the speed at which injured tendons were healed in rats [16]

As you can see, BPC-157’s potential for speeding up the rate of recovery has not gone unnoticed by the biohacking community.

Which is why people are fighting over the perfect BPC-157 dose to take for restoring athletic performance!

BPC-157 For Muscle Growth

Many people have wondered if BPC-157 can help with gaining lean muscle mass.

The main premise is that BPC-157 works similarly to anabolic steroids in maximizing the amount of skeletal muscle mass gained while minimizing body fat accumulation.

Unfortunately, you will not see anybody making this claim.


The only study demonstrating any kind of weight gain was in a study in which BPC-157 was used to cure short bowel syndrome in rats [17].


Weight gain is a common side effect of peptide treatments regardless of the role they serve.


Whether this is due to the peptide’s actions or the individual user consuming more calories, nobody knows for sure.


Some users have reported an increased appetite while using BPC-157, while others have noticed weight loss.


Of course, all of this assumes you are using BPC-157 in isolation and not mixing it with other peptides.


To make a long story short, don’t waste your time using BPC-157 to build more muscle.


It should only be used for the purpose of accelerating healing and recovery from painful injuries.

BPC-157 For Hair Growth

Just like with muscle growth, BPC-157 will not be useful for growing healthier and shiner hair on your scalp.

There are certain peptides such as GHK-Cu which have shown promise in doing so.

Some people believe BPC-157 may be useful because it improves blood flow uniformly throughout the body [18].


So in their train of thought, BPC-157 should help deliver more nutrients and oxygen to your hair follicles, thus leading to hair growth.


But there are no anecdotal reports or scientific studies which prove this to be true. Plus, if you wanted to use BPC-157 for hair growth, you would have to inject it directly into your scalp.


This is both painful and incredibly difficult to do without the guiding hands of a trained surgeon, so don’t bother!

Where to Buy BPC-157 Online? | 2020 Guide

If you’re going to experiment with the BPC-157 dose of your choice, make sure you are sourcing your material from a legitimate vendor.

You want to go for a vendor who has reputable standings from third-party reviews, conducts lab tests to verify the purity of their products, and prices their peptides fairly.


Avoid paying ridiculous fees for BPC-157, while also avoiding products which are clearly labelled with a cheap price tag.


Additionally, you’ll want to watch out for a legal disclaimer on the website which will look something like this:

“This product is intended for laboratory research purposes and is NOT intended for human or animal consumption. It is meant to be handled by licensed medical professionals only. It should not be labeled or used as a food, drug or cosmetic product”

Don’t worry – this is only set in place to provide the company with legal protection.

Now you may be wondering: Who is the BEST BPC-157 online vendor that fulfills all of the above criteria? Look no further, because Peptide Sciences is the only vendor I can vouch for.

They have the highest-grade peptides you will find on the Internet, with purity levels that exceed 99%.


Analytical lab tests are performed at every stage of the manufacturing process so the accuracy, purity and identity of each peptide is reliably verified. No additives, fillers or binding agents are added to the peptides, so you can feel safe knowing you have an extremely high-quality product in your hands.


All of their materials are USA-manufactured, as they are used in clinical trials to demonstrate BPC-157’s potency and therapeutic use.


And don’t worry about shipping: Shipping is FREE on all orders above $200, and a flat fee of $15 is tacked on to any purchase below that number.


Their customer service is truly something to behold, as they are easy to reach and the responses are both speedy and helpful. Don’t waste your money anywhere else –Peptide Sciences can give you the BEST BPC-157 you will ever get your hands on!

Thymosin Beta-4 and BPC-157?

If you are going to use BPC-157 alongside another peptide to further speed up the rate of healing, your best bet would be TB-500.

TB-500 is the synthetic version of Thymosin Beta-4, a naturally occurring protein found in every single tissue of your body.

And like BPC-157, TB-500 has been proven to regenerate various types of tissues and serve other therapeutic purposes such as treating strokes, cardiac damage and stasis ulcers.


My research subjects have informed me of only two crucial differences between the peptides:

  • TB-500 is systemic in its effects, whereas BPC-157 is localized

  • TB-500 is better for treating muscle injuries, and BPC-157 is better suited for treating inflammation

Either way, every single “test subject” I’ve spoken to has remarked on how the compounds work synergistically with one another.

TB-500 is taken twice a week at 2-4 mg per dose, and it is also injected either subcutaneously or intramuscularly.

And if you’re looking for the perfect blend of both peptides to take advantage of their mutually positive healing effects, this is the best blend of TB-500 and BPC-157 I’ve come across.

BPC-157 Dosing | Verdict

Now…

​You know everything there is to know about the perfect BPC-157 dosage for healing any kind of performance-related injury.


Some people will need higher doses if their injury is more severe and/or they are heavier than the average person.


Beginners would be well off starting with a lower BPC-157 dose to give their bodies time to accumulate to the peptide’s effects.


Just make sure the injury fully heals before you hit the gym again!

Buy Buy-157 from our #1 recommended vendor...

References

  1. Sikiric P, Hahm KB, Blagaic AB, Tvrdeic A, Pavlov KH, et al. Stable Gastric Pentadecapeptide BPC 157, Robert’s Stomach

  2. Cytoprotection/Adaptive Cytoprotection/Organoprotection, and Selye’s Stress Coping Response: Progress, Achievements, and the Future. Gut liver. 2020;14(2):153-167. doi: 10.5009/gnl18490.

  3. Brcic L, Brcic I, Staresinic M, Novinscak T, Sikiric P, et al. Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. J Physiol Pharmacol. 2009;60 Suppl 7:191-6.

  4. Grabarevic Z, Tisljar M, Artukovic B, Bratulic M, Dzaja P, et al. The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks. J Physiol Paris. 1997 May-Oct;91(3-5):139-49.

  5. Sikiric P, Seiwerth S, Rucman R, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857–865. doi:10.2174/1570159×13666160502153022.

  6. Tudor M, Jandric I, Marovic A, Gjurasin M, Perovic D, et al. Traumatic brain injury in mice and pentadecapeptide BPC 157 effect. Regul Pept. 2010;160(1-3):26-32. doi: 10.1016/j.regpep.2009.11.012.

  7. Sikiric P, Sikiric PS, Seiwerth S, Rucman R, Turkovic B, et al. Effect of Pentadecapeptide BPC 157 on Gastrointestinal Tract. Front Gastrointest Res. 2010;30:191-201. doi:10.1159/000338435.

  8. Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, et al. Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157. Curr Pharm Des. 2013;19(1):76-83.

  9. Suran J, Kolenc D, Crnic AP, Radic B, Drmic I, et al. The effect of pentadecapeptide BPC 157 in metamphetamine-induced dopaminergic neurotoxicity (1143.11). FASEB J. 2014;28:Suppl1.

  10. Keremi B, Lohinai Z, Komora P, Duhaj S, Borsi K, et al. Antiinflammatory effect of BPC 157 on experimental periodontitis in rats. J Physiol Pharmacol. 2009;60 Suppl 1:115-122.

  11. BPC-157. Retrieved March 17, 2020. examine.com

  12. Peptide Mixing and Dosing Calculator. Retrieved March 20, 2020. http://112.196.20.91/realpeptide/peptide-calculator/

  13. Hope M, Saxby TS. Tendon healing. Foot Ankle Clin. 2007;12(4):553-567.

  14. Mikus D, Sikiric P, Seiwerth S, Petricevic A, Aralica G, et al. Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice. Burns. 2001;27(8):817-827.

  15. Gwyer D, Wragg NM, Wilson SL. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res. 2019;377(2):153-159. doi:10.1007/s00441-019-03016-8.

  16. Perovic D, Kolenc D, Vilic V, Somun N, Drmic D, et al. Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. J Orthop Surg Res. 2019;14(1):199. doi:10.1186/s13018-019-1242-6.

  17. Staresinic M, Sebecic B, Patrlj L, Jadrijevic S, Suknaic S, et al. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J Orthop Res. 2003;2196):976-983.

  18. Sever M, Klicek R, Radic B, Brcic L, Zorocic I, et al. Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats. Dig Dis Sci. 2009;54(1):2070-2083. doi:10.1007/s10620-008-0598-y.

  19. Seiwerth S, Sikiric P, Grabarevic Z, Zoricic I, Hanzevacki M, et al. BPC 157’s effect on healing. J Physiol Paris. 1997;91(3-5):173-178.

References

  1. Sikiric P, Hahm KB, Blagaic AB, Tvrdeic A, Pavlov KH, et al. Stable Gastric Pentadecapeptide BPC 157, Robert’s Stomach

  2. Cytoprotection/Adaptive Cytoprotection/Organop
    rotection, and Selye’s Stress Coping Response: Progress, Achievements, and the Future. Gut liver. 2020;14(2):153-167. doi: 10.5009/gnl18490.

  3. Brcic L, Brcic I, Staresinic M, Novinscak T, Sikiric P, et al. Modulatory effect of gastric pentadecapeptide BPC 157 on angiogenesis in muscle and tendon healing. J Physiol Pharmacol. 2009;60 Suppl 7:191-6.

  4. Grabarevic Z, Tisljar M, Artukovic B, Bratulic M, Dzaja P, et al. The influence of BPC 157 on nitric oxide agonist and antagonist induced lesions in broiler chicks. J Physiol Paris. 1997 May-Oct;91(3-5):139-49.

  5. Sikiric P, Seiwerth S, Rucman R, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857–865. doi:10.2174/1570159×1
    3666160502153022.

  6. Tudor M, Jandric I, Marovic A, Gjurasin M, Perovic D, et al. Traumatic brain injury in mice and pentadecapeptide BPC 157 effect. Regul Pept. 2010;160(1-3):26-32. doi: 10.1016/j.regpep.2009.
    11.012.

  7. Sikiric P, Sikiric PS, Seiwerth S, Rucman R, Turkovic B, et al. Effect of Pentadecapeptide BPC 157 on Gastrointestinal Tract. Front Gastrointest Res. 2010;30:191-201. doi:10.1159/000338435.

  8. Sikiric P, Seiwerth S, Rucman R, Turkovic B, Rokotov DS, et al. Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157. Curr Pharm Des. 2013;19(1):76-83.

  9. Suran J, Kolenc D, Crnic AP, Radic B, Drmic I, et al. The effect of pentadecapeptide BPC 157 in metamphetamine-induced dopaminergic neurotoxicity (1143.11). FASEB J. 2014;28:Suppl1.

  10. Keremi B, Lohinai Z, Komora P, Duhaj S, Borsi K, et al. Antiinflammatory effect of BPC 157 on experimental periodontitis in rats. J Physiol Pharmacol. 2009;60 Suppl 1:115-122.

  11. BPC-157. Retrieved March 17, 2020. examine.com

  12. Peptide Mixing and Dosing Calculator. Retrieved March 20, 2020. http://112.196.20.91/re
    alpeptide/peptide-calculator/

  13. Hope M, Saxby TS. Tendon healing. Foot Ankle Clin. 2007;12(4):553-567.

  14. Mikus D, Sikiric P, Seiwerth S, Petricevic A, Aralica G, et al. Pentadecapeptide BPC 157 cream improves burn-wound healing and attenuates burn-gastric lesions in mice. Burns. 2001;27(8):817-827.

  15. Gwyer D, Wragg NM, Wilson SL. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res. 2019;377(2):153-159. doi:10.1007/s00441-019-03016-8.

  16. Perovic D, Kolenc D, Vilic V, Somun N, Drmic D, et al. Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. J Orthop Surg Res. 2019;14(1):199. doi:10.1186/s13018-019-1242-6.

  17. Staresinic M, Sebecic B, Patrlj L, Jadrijevic S, Suknaic S, et al. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J Orthop Res. 2003;2196):976-983.

  18. Sever M, Klicek R, Radic B, Brcic L, Zorocic I, et al. Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats. Dig Dis Sci. 2009;54(1):2070-2083. doi:10.1007/s10620-008-0598-y.

  19. Seiwerth S, Sikiric P, Grabarevic Z, Zoricic I, Hanzevacki M, et al. BPC 157’s effect on healing. J Physiol Paris. 1997;91(3-5):173-178.

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