BPC-157 Side Effects | The A-Z Guide

bpc-157 side effects

You may have heard rumors about potential BPC-157 side effects​ while reading reviews online.

But is there any validity to them, or are they all speculation?

Let’s find out…


Many elite-level athletes, biohackers and weekend warriors are using BPC-157 to accelerate the speed at which their tendons, ligaments and muscles heal.


Ironically, BPC-157 has not undergone sufficient human clinical trials to verifiably make these claims. So what are the potential side effects of BPC-157? And are they enough of a deal-breaker to render its regenerative properties useless?


The only way to definitively answer this question is by explaining how BPC-157 works in your body.

Buy BPC-157 from the #1 online Peptides vendor in the world: Peptides Sciences

Buy BPC-157 from the #1 online Peptides vendor in the world: Peptides Sciences

P.S: This is not medical or legal advice. This is strictly for entertainment purposes. We are not doctors – nor lawyers. All information below is presented for use on “test subjects” only. Not for human consumption. Please read my disclaimer.

What is BPC-157?

BPC-157 is the synthetic version of naturally occurring peptide that is found and isolated from gastric juice, which is secreted from the gut.

It has recently gathered attention as a regenerative peptide which can help enhance performance and heal several types of injuries.


As early as 1999, researchers were quick to notice its effects in cell cultures and animals [1]:

“…the potentially beneficial effect on pancreas, liver injuries, endothelium and heart damage, i.e. dysrhythmias following reoxygenation, and blood pressure, along with effect on experimental acute/chronic inflammation, wound and fracture (pseudoarthrosis) healing are described”

“Nevertheless, the reported beneficial effects of this stomach pentadecapeptide BPC 157 on different organ lesions appear to be quite convincing, providing all together a particular network reflecting activity of a special peptidergic defence system.

Supportingly, its interactions with many important systems could provide an evident background for the observed protective effects”

What’s most surprising is how BPC-157 has not only maintained a reputation for its healing properties, but has been revealed to have other whole-body effects which were previously undiscovered.

A 2019 study examining BPC-157’s ability to heal spinal cord injuries and restore function in rats commented on the other benefits discovered since then [2]:

“BPC 157 has beneficial effects on inflammation, hemorrhage, and edema after traumatic brain injury, various severe encephalopathies (which follow gastrointestinal and/or liver lesions), NSAID overdose, or insulin overdose seizures and on severe muscle weakness after exposure to the specific neurotoxin cuprizone in a rat multiple sclerosis model or magnesium overdose.”

For these reasons alone, biohackers and athletes have experimentally used this peptide to recover from injuries at a much faster rate than what the body would normally allow.

To put this in context: What would normally take 4-6 weeks for complete recovery can be slashed down to 1-2 weeks with the use of BPC-157.

And while you will hear differing opinions from physicians, some of them have even begun using them to help their patients achieve certain outcomes [3]:

“BPC-157 is a game changer for people who have shoulder issues, tennis elbow, golfers elbow, ligament problems, torn muscles, and it even helps to protect organs like the liver and kidneys”

However, it is important to note the current legal status of BPC-157.

It is currently not considered an illegal substance, nor is it on the list of banned substances in any professional sports organization.

But please do not take this to mean you can freely inject BPC-157 and be considered “clean.”


In fact, there are active efforts right now to add BPC-157 to the list of substances athletes WILL be tested for before a sporting event [4]:

“Recently, our laboratory identified the contents of five confiscated vials. Included in three of these vials were compounds previously reported in an anti-doping context: CJC-1295-DAC (drug affinity complex), ipamorelin, and sermorelin. Additionally, identified and reported here for the first time, were BPC 157 and a variant of mechano-growth factor, MGF R23H.”

“As described, its use in the sporting world as a means of quick injury healing seems apparent. Importantly, however, without proper clinical study, the potential harmful effects of BPC 157 have not yet been documented in detail.”

“… regardless of its capability to enhance athletic performance, this substance should be considered banned under category S0: Non-Approved Substances on the WADA Prohibited List.”

Are these fears based on the reality of athletes enhancing their rate of recovery, or are these precautions unnecessary?

And adding to this, have any harmful side effects of BPC-157 been discovered to date?


To answer this question, it’s important to understand what the body of medical literature has discovered about BPC-157.

BPC-157

Benefits of BPC-157

Bodybuilders and powerlifters would not be injected BPC-157 into their body unless they were gaining tangible benefits from doing so.

Most of the information you will find regarding the benefits of BPC-157 comes from anecdotal reports on online forums and the scientific studies published to date.


So let’s see what is known about BPC-157 as of this writing.

BPC-157 May Reduce The Incidence Of Heart Disease

A study was conducted in 2009 which involved rats treated with Digitalis, a drug used to treat congestive heart failure.

However, Digitalis can sometimes induce irregular heart beats (i.e. arrhythmia) that can lead to other cardiovascular health problems.


BPC-157 was not only effective in reversing Digitalis-induced arrhythmia, but it did so when dosed in isolation [5].


When the researchers attempted to combine BPC-157 with a vasodilator drug known as L-NAME, the results were equivalent to using BPC-157 alone!

BPC-157 Can Inhibit Pain

One of the most devastating consequences of a severe injury is the amount of pain inflicted to the individual.

The pain can be strong enough to limit functional movement and decrease one’s overall quality of life.

In 1993, rats were tested for their reaction to pain using different tests: A “tail pinching” test, and a “hot plate” test whereby the rats were placed on heated surfaces to assess their reaction to the pain.


Here is what they found:

“BPC 157 reduced the nociceptive response in various assays, involving apparently different pathways, including both indirect as well as direct pain stimulation”

In other words, BPC-157 is an analgesic – meaning it works to relieve the pain felt by the subject in question [6].

Moreover, the researchers commented on how the pain reduction of BPC-157 was uniquely different from harmful drugs such as opioids and NSAIDs.


This means BPC-157 may be used as a viable alternative to pain medications known for having deleterious side effects.

BPC-157 Shows Potential In Healing Bone Injuries

​An example of how BPC-157 may be useful for treating injuries can be seen in rabbits who have segmental bone defects.

When I use the term “bone defect”, I am referring to a lack of bone where it is supposed to be in normal circumstances.


Researcher Pedrag Sikiric and his team took rabbits with these bone defects and allowed the injury to remain completely unhealed for 6 weeks.


They then administered BPC-157 in many different ways over 2 weeks: Locally into the bone defect once every few days, intramuscularly once every few days, and intramuscularly every single day at varying dosages (10 nanograms per kilogram or bodyweight, or 10 micrograms).


In every single method of BPC-157 administration, the bone defects were significantly healed [7].


Moreover, the bones were healed uniformly and they returned to their normal structure:

“no evidence for extracortical new bone formation, bony hypertrophy or ectopic bone formation was noted (avoiding the risk of reluctant osteogenesis outside the desired area)”

​In other words, there was no abnormal bone formation or an “overgrowth” of bone.

BPC-157 Can Increase Collagen Synthesis

BPC-157 can not only kick-start the synthesis of collagen tissue, but it can also allow the collagen to organize appropriately [8].

Here is why this is important:


Collagen is an essential protein which serves a structural role in ligaments, muscles, tendons, and other important body parts.


Extending from this, collagen has multiple health benefits [9]:

  • Improved skin health

  • Relief of joint pain

  • Growth of hair and nails

  • Better cardiovascular health
You can now understand why collagen supplements are so widely regarded by health experts!

BPC-157 May Heal Tendon Injuries

Your tendons are responsible for connecting your muscles to your bone.

The Achilles tendon is the largest one in your body, connecting your heel bone to your calf muscles.

It turns out BPC-157 is also potent in healing injuries sustained to the Achilles tendon, at least in the rat study being quoted [10]:

“Stable peptide BPC 157 with combined anti-inflammatory action and induction of early new blood vessel formation facilitates early functional recovery in Achilles tendon to bone healing.”

BPC-157 was proven to be superior to methylprednisolone, an anti-inflammatory drug commonly used for treating arthritis and preventing “rejection” of a new organ during transplant surgeries.

BPC-157 Side Effects | What You MUST Know

Are there any BPC-157 side effects you need to be worried about?

Let’s take a look at what my research subjects have told me. Out of all the studies done in animals and the few human clinical trials that exist, no adverse side effects or toxicity events have been reported.


This even holds true when extremely high doses of BPC-157 were used.


However, peptides in general tend to have a few side effects [11]:

  • Headache

  • Nausea

  • Dizziness/fatigue

  • Slightly elevated blood pressure

  • Redness/pain in the area of injection

  • Increase in appetite

Many of the supposed side effects of BPC-157 arise during the first few injections when the body is getting used to the peptide.

But after a couple of days, the side effects tend to subside.


These side effects may also arise if you are taking much higher dosages of BPC-157 compared to your regular dosing regimen.


Keep in mind that all of this is looking at the BPC-157 peptide in isolation, as side effects may occur if you are dosing other peptides simultaneously.


We’re also assuming you are using the proper dosage of BPC-157 and other lifestyle factors (sleep, diet, training) are appropriately taken care of [12].


In summation, the side effects of BPC-157 are minimal if you are using the peptide responsibly!

BPC-157

BPC-157 Cancer?

One side effect of BPC-157 which gets discussed amongst users is the possibility of causing or aggravating cancer.

This belief comes from the fact that BPC-157 is proangiogenic, meaning it stimulates the formation of new blood cells [13].

However, this claim does not lie on solid ground and cannot be taken at face value.

 

No studies done on BPC-157 to date have shown BPC-157 to initiate the formation of cancer, nor has any connection been found between BPC-157 and the aggravation of existing tumors.

Many more studies done in animals and humans would need to be done in order to substantiate this claim.


One in vitro study done in human melanoma cells found that BPC-157 actually inhibited growth of the cancer cells.


Specifically, the researchers found BPC-157 worked to prevent DNA synthesis in those cells, which means it may be a potent inhibitor of cancer cell growth [14].

Another interesting study was able to successfully BPC-157 in treating cancer cachexia, a condition in which cancer patients suffer significant weight loss and skeletal muscle atrophy [15].

 

So does BPC-157 actually cause cancer? As of now, the answer is unknown to us.


If you are considering BPC-157 and you are worried about this outcome, make sure to speak a licensed medical professional before using it.


You should also seek the guidance of a physician if you start to experience any side effects not mentioned in this article.

Where to Buy BPC-157 Online? | 2020 Guide

You might be wondering about the best place to buy BPC-157 online.

While the side effects of BPC-157 are nothing to worry about, it is assumed you are using the highest-quality of BPC-157 you can get your hands on.


There are many online vendors for therapeutic peptides, but the best one without question is Peptide Sciences.


Here are a few reasons why you should look no further for sourcing pure and potent BPC-157:

  • AWESOME Customer Service: These guys are true professionals. Not only do they respond to every single call and email they get, but they do so in 24 hours and give you a helpful reply. You won’t have to worry about useless “cookie-cutter” answers.

  • FAST International Shipping: Orders in the USA arrive within 2-3 business days (7-10 days for international orders), and products are shipped 24 hours after your order. They charge a flat $15 shipping fee on your order, but it gets waived if your total order is more than $200!

  • HIGHEST Purity Peptides: Through the use of high-performance liquid chromatography and Mass Spectrometry, you are getting nothing less than the peptide itself. Each product is higher than 99% purity without the use of additives, fillers or binding agents

  • EASY Payment: Whether you want to pay with a credit card or cryptocurrency, your payments needs are going to be accommodated.

  • TFA-Free: All peptides created and sold by Peptide Sciences are 100% TFA-free! Trifluoroacetic acid is found in many of the peptides from low quality vendors who import from China. While not getting to deep into the science here, TFA can be exceptionally dangerous.

I have yet to see another vendor which can fulfill all of the above criteria, or do so at the same level.

This is why I have no hesitation whatsoever in recommending Peptide Sciences as the best place to buy BPC-157 online!

Side Effects of BPC-157? | Verdict

So are the BPC-157 side effects a real cause for concern?

If we are going by what has been observed in every single study done on BPC-157 to date, it appears as if there aren’t any. Even if the possibility of BPC-157 causing cancer exists, it is so speculative to the point where worrying about it is meaningless.

Any side effects of BPC-157 experienced by “test subjects” can be attributed to the body getting used to it, really high doses, and/or the use of impure BPC-157.

Even then, many of my research subjects have found any minor inconvenience to be a worthwhile trade-off for rapidly healing injuries and the pains associated with them.

Of course, this does NOT guarantee you will never suffer any BPC-157 side effects.

You should always consult with a physician if you are experiencing any abnormal outcomes as a result of injecting BPC-157 into your body.

Buy BPC-157 from our #1 recommended vendor...

References

  1. Sikiric P. The pharmacological properties of the novel peptide BPC 157 (PL-10). Inflammopharmacology. 1999;7(1):1-14.

  2. Perovic D, Kolenc D, Bilic V, et al. Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. J Orthop Surg Res. 2019;14(1):199. doi:10.1186/s13018-019-1242-6.

  3. BPC-157. Retrieved March 20, 2020. facebook.com

  4. Cox HD, Miller GD, Eicher D. Detection and in vitro metabolism of the confiscated peptides BPC 157 and MGF R23H. Drug Test Anal. 2017;9(10):1490-1498. doi:10.1002/dta.2152.

  5. Dalenovic D, Bencic ML, Udovicic M, Simonji K, Hanzevacki JS, et al. Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system. Regul Pept. 2009;156(1-3):83-9. doi:10.1016/j.regpep.2009.05.008.

  6. Sikiric P, Gyires K, Seiwerth S, Gravarevic Z, Rucman R, et al. The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity. Inflammopharmacology. 1993;2:121-127. doi:10.1007/BF02659088

  7. Sebecic B, Nikolic V, Sikiric P, Seiwerth S, Sosa T, et al. Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation. Bone. 1999;24(3):195-202.

  8. Tkalcevic VI, Cuzic S, Brajsa K, Mildner B, Bokulic A, et al. Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression. Eur J Pharmacol. 2007;570(1-3):212-221.

  9. Top 6 Benefits of Taking Collagen Supplements. Retrieved March 21, 2020. healthline.com

  10. Krevic A, Majerovic M, Jelic I, Seiwerth S, Sikiric P. Modulation of early functional recovery of Achilles tendon to bone unit after transection by BPC 157 and methylprednisolone. Inflamm Res. 2008;57(5):201-210. doi:10.1007/s00011-007-7056-8.

  11. Performance & image enhancing drugs. Retrieved March 19, 2020. adj.org.au

  12. Peptide Mixing and Dosing Calculator. Retrieved March 20, 2020. http://112.196.20.91/realpeptide/peptide-calculator/

  13. Seiwerth S, Brcic L, Vuletic LB, Kolenc D, Aralica G, et al. BPC 157 and blood vessels. Curr Pharm Des. 2017;20(7):1121-1125.

  14. Radeljak S, Seiwerth S, Sikiric P. BPC 157 inhibits cell growth and VEGF signalling via the MAPK kinase pathway in the human melanoma cell line. Melanoma Res. 2004;14(4):A14-A15.

  15. Kang EA, Han YM, An JM, Park YJ, Sikiric P, et al. BPC157 as Potential Agent Rescuing from Cancer Cachexia. Current Pharm Des. 2018;24(18):1947-1956. doi:10.2174/1381612824666180614082950.

References

  1. Sikiric P. The pharmacological properties of the novel peptide BPC 157 (PL-10). Inflammopharmacology. 1999;7(1):1-14.

  2. Perovic D, Kolenc D, Bilic V, et al. Stable gastric pentadecapeptide BPC 157 can improve the healing course of spinal cord injury and lead to functional recovery in rats. J Orthop Surg Res. 2019;14(1):199. doi:10.1186/s13018-019-1242-6.

  3. BPC-157. Retrieved March 20, 2020. facebook.com

  4. Cox HD, Miller GD, Eicher D. Detection and in vitro metabolism of the confiscated peptides BPC 157 and MGF R23H. Drug Test Anal. 2017;9(10):1490-1498. doi:10.1002/dta.2152.

  5. Dalenovic D, Bencic ML, Udovicic M, Simonji K, Hanzevacki JS, et al. Inhibition of methyldigoxin-induced arrhythmias by pentadecapeptide BPC 157: a relation with NO-system. Regul Pept. 2009;156(1-3):83-9. doi:10.1016/j.regpep.20
    09.05.008.

  6. Sikiric P, Gyires K, Seiwerth S, Gravarevic Z, Rucman R, et al. The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity. Inflammopharmacology. 1993;2:121-127. doi:10.1007/BF02659088

  7. Sebecic B, Nikolic V, Sikiric P, Seiwerth S, Sosa T, et al. Osteogenic effect of a gastric pentadecapeptide, BPC-157, on the healing of segmental bone defect in rabbits: a comparison with bone marrow and autologous cortical bone implantation. Bone. 1999;24(3):195-202.

  8. Tkalcevic VI, Cuzic S, Brajsa K, Mildner B, Bokulic A, et al. Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression. Eur J Pharmacol. 2007;570(1-3):212-221.

  9. Top 6 Benefits of Taking Collagen Supplements. Retrieved March 21, 2020. healthline.com

  10. Krevic A, Majerovic M, Jelic I, Seiwerth S, Sikiric P. Modulation of early functional recovery of Achilles tendon to bone unit after transection by BPC 157 and methylprednisolone. Inflamm Res. 2008;57(5):201-210. doi:10.1007/s00011-007-7056-8.

  11. Performance & image enhancing drugs. Retrieved March 19, 2020. adj.org.au

  12. Peptide Mixing and Dosing Calculator. Retrieved March 20, 2020. http://112.196.20.91/rea
    lpeptide/peptide-calculator/

  13. Seiwerth S, Brcic L, Vuletic LB, Kolenc D, Aralica G, et al. BPC 157 and blood vessels. Curr Pharm Des. 2017;20(7):1121-1125.

  14. Radeljak S, Seiwerth S, Sikiric P. BPC 157 inhibits cell growth and VEGF signalling via the MAPK kinase pathway in the human melanoma cell line. Melanoma Res. 2004;14(4):A14-A15.

  15. Kang EA, Han YM, An JM, Park YJ, Sikiric P, et al. BPC157 as Potential Agent Rescuing from Cancer Cachexia. Current Pharm Des. 2018;24(18):1947-1956. doi:10.2174/138161282
    4666180614082950.

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