GHK-Cu Dosage Calculator and Guide | What You Must Know

ghk-cu dosage calculator

Curious about the best GHK-Cu dosage for your bodybuilding, skin repair, and hair growth?

Then you’ve come to the perfect place.

 

​The good news? It seems this stuff actually works. There have been a ton of studies that found GHK-Cu injections and creams can have a significant effect on your body’s ability to heal itself, as well as creating fresh, younger-looking skin.


It’s also ideal for guys with thinning hair, since GHK-Cu stimulates hair growth and protects hair follicles from damage.


If you’re interested in any of those effects, you’ll want to try out GHK-Cu. But what is an appropriate and effective GHK-Cu dosage?


Well, we’re here for you. In this article, we’ll break down the crazy benefits of this copper peptide — as well as how to choose the optimal GHK-Cu dose for your needs.

Buy GHK-Cu from the #1 online Peptides vendor in the world: Peptides Sciences

Buy GHK-Cu from the #1 online Peptides vendor in the world: Peptides Sciences

P.S: This is not medical or legal advice. This is strictly for entertainment purposes. We are not doctors – nor lawyers. All information below is presented for use on “test subjects” only. Not for human consumption. Please read my disclaimer.

What is GHK-Cu?

GHK-Cu is a peptide, which means it’s a short chain of amino acids. It’s made up of three amino acids: Glycine, Histidine, and Lysine. Together these are called GHK.

GHK bonds easily to copper and becomes GHK-Cu. That’s why it’s also called copper peptide or copper tripeptide. GHK-Cu is produced naturally in our bodies and you can find it in the blood, in saliva, and in urine.

The reason​ that’s a big deal is that GHK-Cu seems to play a big role in repairing the DNA in our cells [1]. DNA is essentially a blueprint that cells use when they split and create new cells. When the DNA gets damaged, as is normal over time, that can result in poorer duplication of cells and impaired ability to generate new tissue. GHK-Cu helps repair and reset the DNA so that the tissue grows better [1].

When we age, the genes that are involved in inflammation and tissue destruction become more active. The genes that regenerate and repair tissue become less active. GHK-Cu turns back the clock: it reactivates the regenerative genes and deactivates the inflammatory and destructive ones [1].

It has also been found to be involved in a number of other processes that support tissue creation. It’s pretty complex biology, but, for example, it’s been found to:

  • Stimulate the synthesis of collagen in skin cells [2]

  • Increase the accumulation of protein [2]

  • Increase synthesis of decorin [3]

  • Stimulate the synthesis of metalloproteinases

  • Suppresses the production of the inflammatory

  • cytokine interleukin-6 [1]

  • Stimulates antioxidant gene activity [1]
Basically, its role is to help the body break down old tissue, repair DNA, and create new, healthier tissue. If you want rejuvenation and healthier cells, GHK-Cu is for you.
GHK-Cu

Benefits of GHK-Cu?

There have been a ton of reported benefits of GHK-Cu. Here’s a short list of some of the coolest things that science has discovered that copper tripeptide can do:

  1. Repairing wounds [1]

  2. Antibacterial effects and infection reduction [15]

  3. Anti-tumor and cancer suppression [1]

  4. Skin repair, wrinkle reduction, and anti-aging effects [11]

  5. Tissue remodeling [14]

  6. Lung and gut tissue healing [1]

  7. GHK-Cu hair growth [1]

  8. Nerve regeneration [16]

  9. Anti-pain [12]

  10. Anti-anxiety effects [12]

  11. Anti-agression effects [12]

  12. Antioxidant protection [12]
As one researcher said, “[GHK-Cu’s] ability to reverse gene expression back to health warrant its use as a dietary supplement to support health and vitality of skin, hair and the entire body.”

GHK-Cu Dosage Guide | What You MUST Know

Researchers generally consider GHK-Cu a very safe molecule [12]. As long-time GHK-Cu peptide researcher Loren Pickart and his research colleagues have said, “no issues have ever arisen during its use as a skin cosmetic or in human wound healing studies” [1].

Having said that, it’s good to have a sense of GHK-Cu dosing. Here’s what we’ve determined from the available research and advice online.

Minimal effective dose

We don’t know what the minimal effective dose for this peptide is yet; we need more research to determine that [4].

Effective dose

Studies suggest there is a range that could be effective and that it depends on how it is delivered.

Injections: GHK-Cu injections are an effective way to get systemic healing, skin rejuvenation, and hair growth.

  • Researchers estimate daily GHK-Cu dosing of 100–200 mg will produce therapeutic actions in humans [1].

  • 1.1 mg/kg (77 mg for a 70kg person) has been found to produced healing effects [5].

  • You may need much less than that [1].

Skin cream and skin patch: GHK-Cu skin creams and patches seem to be able to pass therapeutically effective amounts of copper peptide through the skin and into your body [6].

  • 0.5 micrograms (μgs) /kg seems to be effective as a daily dose for lowering anxiety. That would be 35 μgs for a 70kg person [7]. Not this is micrograms, not milligrams. It’s much less.

  • 50 milligrams (mg) seems to be effective as a person’s daily dose for systemic healing [4].

Liposomal Encapsulated Oral Tablet: Regular pill forms for GHK probably won’t work because it would be broken down in the intestines. But some sellers of oral tablets that are liposomal encapsulated may work [8].

  • Researchers suggest a good safe starting dose for human research is about 10 mg, but this may not be enough to see positive results [4].

Lethal Dose

GHK can lower blood pressure, so it could cause problems with a big enough dose. However, the lethal dose of GHK-Cu peptide is very high; it would be about 21,000 mg for a 70kg human (or about 330 mg/kg). That’s over 300 times what has been found to be an effective dose [5].

Recommended Dose

Injections: Our recommendation for injections, which is consistent with fitness experts [9], is the following:

  • GHK-Cu Dose: 1.5 mg per day, injected subcutaneously or intramuscularly.

  • Frequency: 1 per day. You can also split the dose into several injections.

  • Duration: 5-10 days.

  • Cycle: repeat once a year, or as desired.

Again, this is a low dose. You should be able to safely increase quite a bit—perhaps up to 200 mg per day. But start low and then adjust as you go.

Skin creams: For GHK-Cu creams, you can apply as needed. It appears to be non-toxic and non-irritating as a topical cream [1].


Cosmetic studies usually applied skin creams once or twice a day to affected areas—usually the face for skin tightening and wrinkles, the scalp for hair growth, or other areas for scars or wound healing [10].


As always, you should consult with a physician before taking any supplements or substances.

GHK-Cu

GHK-Cu For Beginners

Dosing guidelines were difficult to arrive at because there does not seem to be a consensus among scientists. However, after a lot of reading, we did manage to find some guidelines for GHK-Cu in the scientific literature.

First, the dose you use depends on the delivery method you choose. There appear to be several effective delivery methods:

GHK-Cu For Anti-Aging/Skin

GHK-Cu is probably best known for its anti-aging skin properties. It has been very well-studied as an anti-aging agent and this is why it’s such a popular ingredient in cosmetics.

In one study of women who had skin that had been aged by sun exposure, GHK-Cu removed visible signs of aging after 12 weeks. It improved skin firmness, elasticity, and clarity as well as reduced wrinkles and fine lines [11]. It showed similar results in several other clinical trials. It has better results than vitamin K, vitamin C, and retinoic acid in reducing aged skin [10, 11].

GHK-Cu has been shown to [11]:

  • Tighten skin

  • Improve elasticity and firmness

  • Improve skin density

  • Reduce deep wrinkles and fine lines

  • Reduce hyperpigmentation and sun damage.

GHK-Cu For Healing

GHK-Cu is a powerful healing agent. It’s not only been shown to help wounds close faster with less chance of infection, but it also seems to be involved in healing ulcers and regenerating lung tissue [1]. It does that by repairing DNA, elevating levels of antioxidant enzymes, contracting wounds, and speeding up tissue growth.

More than that, there have been a few studies that suggest GHK-Cu peptide helps slow down or prevent cancerous tissue from forming [3, 4].

GHK-Cu For Muscle Growth

We’ve searched the literature to see what the effect of GHK-Cu on muscle growth is, and so far there doesn’t seem to be any published studies that look at this directly. Still, GHK-Cu is probably useful to you if you regularly hit the gym.

Why? Because it helps your body to repair damaged tissue.


We know that muscle growth happens after you tear muscle fibers. Lifting heavy weights at the gym damages the muscle fibers and your body responds by repairing them as well as creating more. That’s how you build muscle.


Since GHK-Cu has been shown to be a powerful tissue regenerator and healer, it makes sense that you could expect it to help you recover faster from your gym sessions.


It’s also systemic, which means if you take GHK-Cu injections in your thigh, it will cause healing all over your body. So if you did a full upper-body workout, injecting GHK-Cu anywhere will help your body repair all the upper body muscles that need it, not just the ones at the injection site.

GHK-Cu For Hair Growth

Losing some hair? GHK-Cu may be a great option for you: Hair growth is another of the benefits that copper peptide is known for.

A number of studies have established that GHK improves hair growth in a few ways [12, 13, 14]:

  • Improves hair growth

  • Improves hair thickness

  • In enlarges the size of the hair follicles

In fact, it appears that GHK-Cu may actually be as effective as other established hair treatments, but without the side effects [13].

Where to Buy GHK-Cu Online? | 2020 Guide

If you’re looking for GHK-Cu injections, Peptide Science is the best place to buy GHK-Cu online. They have research-grade peptides, which means you’re getting pure peptides with no filler. Not only are they the best for quality but they also have:
  • Easy, secure, and convenient payment options. They accept all major credit cards, but they also accept cryptocurrencies.

  • Convenient shipping. They ship anywhere in the world. If you’re within the US, your package will get to you within 3 days.

  • Great customer service. They’re friendly and helpful. If you have any issues, you can get in touch with an actual person who will work hard to resolve your issue.

We’ve had only great experiences and highly recommend them.

If you’re looking for GHK-Cu skin creams, our go-to is Aseir Custom. Their products are all designed to leave your skin fresh and glowing. They also ship anywhere in the world and offer a great refund policy.

How to Order GHK-Cu in Your Country

Both Peptide Science and Aseir Custom accept orders from all over the world. To order GHK-Cu injections from any country, simply visit their website and place an order.

You should receive your product within 7-10 business days.

GHK-Cu

GHK-Cu Dosage | Verdict

GHK-Cu shows huge promise as a rejuvenating agent. And there’s a reason for the craze: rarely have the claims of a substance that can do so much been supported by so much evidence. This stuff might actually work.

If you’re looking to have your body repair itself like it used to, GHK-Cu is for you. If you’re looking for the beautiful, young-looking skin of your past, GHK-Cu can help. And if you want a full head of thick hair, GHK-Cu is as effective as any of the other treatment options.

It’s safe and effective. What more can you ask for?

Buy GHK-Cu from our #1 recommended vendor...

References

  1. Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2014). GHK and DNA: resetting the human genome to health. BioMed Research International, 151479. https://doi.org/10.1155/2014/151479

     

  2. Maquart, F. X., Pickart, L., Laurent, M., Gillery, P., Monboisse, J. C., & Borel, J. P. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide‐copper complex glycyl‐L‐histidyl‐L‐lysine‐Cu2+. FEBS letters, 238(2), 343-346. doi:10.1016/0014-5793(88)80509-x

  3. Siméon, A., Wegrowski, Y., Bontemps, Y., & Maquart, F. X. (2000). Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide–copper complex glycyl-l-histidyl-l-lysine-Cu2+. Journal of Investigative Dermatology, 115(6), 962-968.

  4. Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2017). The effect of the human peptide GHK on gene expression relevant to nervous system function and cognitive decline. Brain Sciences, 7(2), 20.

  5. Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2012). The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxidative medicine and cellular longevity, 2012. Doi: 10.1155/2012/324832

  6. Hostynek, J. J., Dreher, F., & Maibach, H. I. (2010). Human skin retention and penetration of a copper tripeptide in vitro as function of skin layer towards anti-inflammatory therapy. Inflammation Research, 59(11), 983-988.

  7. Bobyntsev, I. I., Chernysheva, O. I., Dolgintsev, M. E., Smakhtin, M., & Belykh, A. E. (2015). Effect of Gly-His-Lys peptide and its analogs on pain sensitivity in mice. Eksperimental’naia i Klinicheskaia Farmakologiia, 78(1), 13-15.

  8. Erdem, S., & Türkoülu, M. (2010). Glycyl-L-Histidyl-L-Liysine-Cu (2+) loaded liposome formulations. Marmara Pharmaceutical Journal, 14(2), 91-97.

  9. Ben Green Fitness (n.d.). The Little-Known Russian Wonder Compound & The Fringe Future Of Anti-Aging Medicine. https://bengreenfieldfitness.com/article/anti-aging-articles/how-to-use-peptides/

  10. Abdulghani, A. A., Sherr, A., Shirin, S., Solodkina, G., Tapia, E. M., Wolf, B., & Gottlieb, A. B. (1998). Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin-A pilot clinical, histologic, and ultrastructural study. Disease Management and Clinical Outcomes, 4(1), 136-141.

  11. Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2015). GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. BioMed Research International, 648108. https://doi.org/10.1155/2015/648108

  12. Pickart, L., & Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences, 19(7), 1987.

  13. Uno, H., & Kurata, S. (1993). Chemical agents and peptides affect hair growth. Journal of Investigative Dermatology, 101(1), S143-S147. https://doi.org/10.1016/0022-202X(93)90516-K

  14. Pickart, L. (2008). The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition, 19(8), 969-988.

  15. Mulder, G. D., Patt, L. M., Sanders, L., Rosenstock, J., Altman, M. I., Hanley, M. E., & Duncan, G. W. (1994). Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl‐l‐histidyl‐l‐lysine copper. Wound Repair and Regeneration, 2(4), 259-269.

  16. Ahmed, M. R., Basha, S. H., Gopinath, D., Muthusamy, R., & Jayakumar, R. (2005). Initial upregulation of growth factors and inflammatory mediators during nerve regeneration in the presence of cell adhesive peptide‐incorporated collagen tubes. Journal of the Peripheral Nervous System, 10(1), 17-30.

References

  1. Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2014). GHK and DNA: resetting the human genome to health. BioMed Research International, 151479. https://doi.org/10.1155/
    2014/151479

     

  2. Maquart, F. X., Pickart, L., Laurent, M., Gillery, P., Monboisse, J. C., & Borel, J. P. (1988). Stimulation of collagen synthesis in fibroblast cultures by the tripeptide‐copper complex glycyl‐L‐histidyl‐L‐lysine‐Cu2+. FEBS letters, 238(2), 343-346. doi:10.1016/0014-5793(88)80509-x

  3. Siméon, A., Wegrowski, Y., Bontemps, Y., & Maquart, F. X. (2000). Expression of glycosaminoglycans and small proteoglycans in wounds: modulation by the tripeptide–copper complex glycyl-l-histidyl-l-lysine-Cu2+. Journal of Investigative Dermatology, 115(6), 962-968.

  4. Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2017). The effect of the human peptide GHK on gene expression relevant to nervous system function and cognitive decline. Brain Sciences, 7(2), 20.

  5. Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2012). The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxidative medicine and cellular longevity, 2012. Doi: 10.1155/2012/324832

  6. Hostynek, J. J., Dreher, F., & Maibach, H. I. (2010). Human skin retention and penetration of a copper tripeptide in vitro as function of skin layer towards anti-inflammatory therapy. Inflammation Research, 59(11), 983-988.

  7. Bobyntsev, I. I., Chernysheva, O. I., Dolgintsev, M. E., Smakhtin, M., & Belykh, A. E. (2015). Effect of Gly-His-Lys peptide and its analogs on pain sensitivity in mice. Eksperimental’naia i Klinicheskaia Farmakologiia, 78(1), 13-15.

  8. Erdem, S., & Türkoülu, M. (2010). Glycyl-L-Histidyl-L-Liysine-Cu (2+) loaded liposome formulations. Marmara Pharmaceutical Journal, 14(2), 91-97.

  9. Ben Green Fitness (n.d.). The Little-Known Russian Wonder Compound & The Fringe Future Of Anti-Aging Medicine. https://bengreenfieldfitn
    ess.com/article/anti-aging-articles/how-to-use-peptides/

  10. Abdulghani, A. A., Sherr, A., Shirin, S., Solodkina, G., Tapia, E. M., Wolf, B., & Gottlieb, A. B. (1998). Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin-A pilot clinical, histologic, and ultrastructural study. Disease Management and Clinical Outcomes, 4(1), 136-141.

  11. Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2015). GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration. BioMed Research International, 648108. https://doi.org/10.1155/
    2015/648108

  12. Pickart, L., & Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. International Journal of Molecular Sciences, 19(7), 1987.

  13. Uno, H., & Kurata, S. (1993). Chemical agents and peptides affect hair growth. Journal of Investigative Dermatology, 101(1), S143-S147. https://doi.org/10.1016/
    0022-202X(93)90516-K

  14. Pickart, L. (2008). The human tri-peptide GHK and tissue remodeling. Journal of Biomaterials Science, Polymer Edition, 19(8), 969-988.

  15. Mulder, G. D., Patt, L. M., Sanders, L., Rosenstock, J., Altman, M. I., Hanley, M. E., & Duncan, G. W. (1994). Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl‐l‐histidyl‐l‐lysine copper. Wound Repair and Regeneration, 2(4), 259-269.

  16. Ahmed, M. R., Basha, S. H., Gopinath, D., Muthusamy, R., & Jayakumar, R. (2005). Initial upregulation of growth factors and inflammatory mediators during nerve regeneration in the presence of cell adhesive peptide‐incorporated collagen tubes. Journal of the Peripheral Nervous System, 10(1), 17-30.

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