Research
GHK-Cu Fact Sheet
| Molecular formula: |
C17H33N5O4 |
| Molecular weight: |
371.5 g/mol |
| Purity: |
99% |
| Sequence: |
glycyl-l-histidyl-l-lysine |
| Research Applications: |
- Wound healing
- Antioxidant
- Anti-inflammatory
- Skin rejuvenation
- Hair growth
|
GHK-Cu (Copper Peptide) Overview
GHK-Cu, also known as copper peptide GHK-Cu, is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. It was first isolated from human plasma and has since been found in other areas of the body, such as saliva and urine. Copper peptides are naturally occurring protein fragments that have a strong attraction to copper ions and are thought to play a vital role in the normal functioning of the body. GHK-Cu has been the subject of numerous studies, which have revealed several roles and benefits in the human body.
GHK-Cu and Wound Healing
GHK-Cu has been shown to improve the healing of ischemic open wounds in rats, leading to faster healing. It stimulates the synthesis of collagen, elastin, and glycosaminoglycans in the skin, which are essential for wound healing. In the same study, wounds treated with GHK-Cu showed a decreased concentration of metalloproteinases 2 and 9, which are enzymes involved in the breakdown of extracellular matrix during the wound healing process [R].
GHK-Cu stimulates collagen and decorin production, which are essential for tissue regeneration and wound healing. It also increases cellular stemness and secretion of trophic factors by mesenchymal stem cells. GHK-Cu also promotes skin remodeling, which is crucial for wound healing and regeneration [R].
GHK-Cu Antioxidant and Anti-Inflammatory Effects
GHK-Cu (glycyl-l-histidyl-l-lysine copper) has been shown to have antioxidant and anti-inflammatory effects in various studies. GHK-Cu may prevent oxidative stress in the skin by regulating copper levels and influencing the activity of various antioxidant genes [R].
GHK-Cu has also been shown to ameliorate lipopolysaccharide-induced acute lung injury in mice by suppressing inflammation and reducing oxidative damage [R].
GHK-Cu and Skin Remodeling and Regeneration
GHK-Cu has been shown to improve the appearance of aging skin in clinical studies. Both GHK and GHK-Cu have been found to have anti-inflammatory and tissue remodeling properties [R].Â
GHK-Cu at a 1nM concentration enhances the expression of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) in human dermal fibroblasts exposed to radiation. These factors promote the formation of blood vessels and improve blood flow to injured tissues. The ability of GHK and its Cu chelate to promote skin remodeling, wound healing, and regeneration, and its prominent antioxidant and anti-inflammatory effects are qualities that help with healthy aging [
R].
GHK-Cu and Promotion of Blood Vessel Growth
GHK-Cu has demonstrated the ability to stimulate blood vessel and nerve growth, enhance the production of collagen, elastin, and glycosaminoglycans, and aid in the functioning of different tissues.
Copper plays a crucial role in stimulating the growth of blood vessels and acts as a necessary co-factor in the signaling processes involved in angiogenesis. The combination of GHK-Cu with copper (II)Â has been found to dramatically increase cell proliferation, differentiation, and production in a synthetic cryogel extracellular matrix (ECM) model [
R,
R].
GHK-Cu and Hair Growth
GHK-Cu has been found to increase hair growth and thickness, as well as enlarge hair follicle size. GHK-Cu stimulates collagen synthesis by fibroblasts, which is necessary for hair growth and thickness [R].
GHK-Cu promotes the growth of human hair follicles by stimulating the proliferation and precluding the apoptosis of dermal papilla cells (DPCs). GHK-Cu has strong inhibitory effects on dihydrotestosterone (DHT), which is a key factor in hair loss regulation [R].
FAQ
What is GHK-Cu?
GHK-Cu, also known as copper peptide GHK-Cu, is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine. It occurs naturally and was initially discovered in human plasma. It can also be found in saliva and urine. GHK-Cu has been extensively studied and has shown the ability to regulate the expression of many human genes, often restoring gene expression to a more favorable state.
Synthetic GHK-Cu is used in various cosmetic products, such as serums and creams, to provide benefits to the skin. Additionally, GHK-Cu has shown potential in peptide therapy for growth hormone, hair and skin, weight loss, immune system support, repair, neurogenic/neurorestorative, muscle building, libido, endocrine regulation, and sexual health.
What Copper Peptide GHK-Cu Benefits Have Been Studied?
Several potential benefits and applications of the copper-binding peptide GHK-Cu have been studied.
- Skin delivery and cosmetic applications: Liposomes have been investigated as carriers for GHK-Cu to deliver the peptide to the skin. GHK-Cu-loaded liposomes demonstrated inhibition of elastase activity, potentially reducing elastin degeneration and supporting skin structural integrity [R].
- Skin remodeling and anti-aging: GHK-Cu has been shown to increase production of key skin proteins like collagen and modulate the skin remodeling process by stimulating both breakdown and synthesis of dermal matrix components, exhibiting anti-aging and tissue renewing properties [R].
- Wound healing: Stimuli-responsive polymers based on polyaspartic acid, 2-acrylamido-2-methylpropane sulfonic acid, and sodium alginate were developed for controlled release of GHK-Cu. In vivo studies showed promising results for wound closure and healing [R].
- Anti-inflammatory and protective effects in acute lung injury: GHK-Cu treatment reduced reactive oxygen species production, increased superoxide dismutase activity, and decreased pro-inflammatory cytokines in lipopolysaccharide-induced acute lung injury models, suggesting a potential therapeutic approach [R].
- Antioxidant and antiglycant properties for neurodegenerative disorders: A new biotin-GHK conjugate (BioGHK) was synthesized and studied for its antioxidant, antiglycant, and antiaggregant properties, suggesting potential applications in treating or preventing biochemical reactions associated with neurodegenerative disorders [R].
Where to Buy GHK-Cu
GHK-Cu can be purchased online from reputable biotech suppliers such as Limitless Biotech. Limitless offers a wide selection of USA made peptides for sale online for scientific research and development.
Our extensive range of products undergoes rigorous third-party testing to verify the sequential signatures of all research peptides for sale. With our commitment to quality, most orders are promptly sent out on the same day they are placed, accompanied by our unwavering dedication to providing exceptional customer service.
