Ipamorelin | Review of Benefits, Dosage, Side Effects, and More

Curious about Ipamorelin? Wondering if the peptide can be used for losing weight, growing muscle, or gaining energy? Then you’ve come to the right spot.

Bodybuilders and people looking to lose weight are increasingly turning to Ipamorelin. The peptide may help them get the most out of their workouts. But many people don’t realize that this research peptide may have a ton of other great benefits, including improved sleep, bone health, and making you look younger.


Here, we’ll give you a thorough Ipamorelin review. Keep reading for the low-down on Ipamorelin benefits, dosage, side effects, and information on where to buy it.

Buy Ipamorelin from the #1 online Peptides vendor in the world: Peptides Sciences

Buy Ipamorelin from the #1 online Peptides vendor in the world: Peptides Sciences

P.S: This is not medical or legal advice. This is strictly for entertainment purposes. We are not doctors – nor lawyers. All information below is presented for use on “test subjects” only. Not for human consumption. Please read my disclaimer.

What is Ipamorelin?

Ipamorelin is a peptide made up of five amino acids. Amino acids are also the building blocks of protein. Ipamorelin is derived from Growth Hormone Releasing Peptide 1 (GHRP-1). Since it is chemically similar to GHRP-1, it activates the same receptors as GHRP-1 and has similar effects.

The biggest effect of Ipamorelin is stimulating your body to produce more natural growth hormones [1]. Growth hormones, also known as human growth hormones (HGH), stimulate cell growth, reproduction, and regeneration [2]. They are essential for building new cells, including muscle and skin cells.


Human growth hormones (HGH) are naturally produced in the body’s pituitary gland. But sometimes the pituitary gland doesn’t produce enough of it—or any at all. Ipamorelin is a potent growth hormone stimulator, helping your body produce more growth hormones and build new tissue quicker.


The second thing that Ipamorelin does is suppress somatostatin. Somatostatin is a hormone that inhibits the production of growth hormone. So by suppressing somatostatin, Ipamorelin creates an environment that enables more growth hormones to be released, and ultimately, builds muscle and tissue faster.


How does it work?


Basically it mimics the activity of other things that release growth hormones. In science-speak, it mimics the actions of GHRP-2 and GHRP-6 by acting on GHRP receptors. When it does this, it induces the release of growth hormone. Basically, the result is that you get more growth hormone in your body, which is essential in building muscle.


One of the great things about Ipamorelin is that it doesn’t affect cortisol levels. Cortisol is a hormone, often associated with stress. It does several things in your body, but one effect of increased cortisol over the long-term is that it can increase fat and decrease muscle mass in the body [3]. So if you’re looking to bodybuild or build muscle, you don’t want too much cortisol over a long period.


Other drugs that increase growth hormone often also release cortisol at the same time. But Ipamorelin doesn’t, which is one reason it’s so great and is considered one of the best growth hormone-releasing peptides.


One thing Ipamorelin isn’t is an anabolic steroid. Steroids are hormones that bind to androgen receptors. Ipamorelin is a peptide and doesn’t do anything to androgen receptors. That means that it doesn’t have any of the crazy side-effects that steroids can have.

Does Ipamorelin Actually Work?

The short answer is “yes”.


The long answer is that it depends on what you want it to do. For example, lots of research has found that Ipamorelin really does result in greater blood growth hormone levels, which in turn, helps regenerate tissue and build muscle [1, 4].

 

In terms of anecdotal evidence, lots of bodybuilders report significant effects of Ipamorelin on body composition. They build muscle and lose fat much easier [5].

For example, some people say that they found as they were bodybuilding, their muscles grew too fast for their tendons. They used Ipamorelin to help the tendons strengthen up [5].

It was also effective for reducing the delayed onset muscle soreness (DOMS) that accompanies strength training [5]. So they recovered faster and got back to the gym sooner.

Some people also talk about the great improvement to skin and nails as well as the improved quality of sleep [5].

But it doesn’t do everything. Research on Ipamorelin started by testing it to see if it could help gastrointestinal issues. In the end, it appears that it is not very good at that [6].

Ipamorelin Before and After

Here are some examples of what individuals can expect from Ipamorelin before and after using it.

Before Ipamorelin

  • You might have a relatively low natural production of growth hormones

  • Athletes may experience severe DOMS that lasts for a long time

  • You might have excessive fat, be obese, or have a difficult time losing weight [7]

  • Your body mass from fat is relatively high and body mass from muscle is low

  • Your skin lacks elasticity and may have wrinkles

After Ipamorelin

  • Your body’s growth hormone production will increase [6]

  • You will recover from workouts and injuries faster

  • You will experience fat loss as the lipids in your body are broken down [7]

  • You will gain lean tissue, including muscle mass [7]

  • Your skin will take on a younger look [8]
If these effects are valuable to you, you should check out Ipamorel

Ipamorelin Benefits and Uses

Ipamorelin benefits are huge. But keep in mind that they are all really the benefits of HGH. All Ipamorelin really does is stimulate your body to produce more HGH naturally.

By stimulating more production Ipamorelin HGH levels increase and have a lot of really great effects. Here is a list of all the Ipamorelin benefits you can expect, backed up with research.

Muscle Growth

HGH is an essential component of the development of all body tissues, including muscles. Because it increases the availability of HGH, Ipamorelin has been shown to effectively increase muscle mass [4].


It helps you build lean muscle mass and helps burn off excess body fat [9]. That’s why bodybuilders and weight lifters love it so much.


Of course, it only works to build muscle when you use it in combination with a regular workout program [4]. No pain, no gain!

Better Recovery From Workouts

As all bodybuilders know, muscles don’t grow while you workout—they grow while you recover. Working out damages the muscles. Your body then repairs them by fusing the damaged muscle fibers and creating new ones. This results in muscle hypertrophy or growth [10].

Ipamorelin causes an increase in growth hormone, which in turn speeds up the repair and the creation of muscles. Because it makes repairing muscles more effective, your recovery from your workouts will go much faster, making you able to get back to the gym sooner. It can also help you recover from injuries [11].

More Energy and Improved Sleep

Ipamorelin and other growth hormone-releasing peptides (GHRPs) stimulate growth hormone production, which helps boost the body’s metabolism. It helps break down the food you eat into usable energy. People that use Ipamorelin find that they feel like they have much more energy than they did before using it [12].

It also helps you get a deeper, better quality sleep. Studies find that it increases the deep, slow-wave sleep cycle helping you feel more well-rested [13]. Good quality sleep is crucial for people trying to lose weight, and also is essential for bodybuilding.

Reduce Body Fat and Weight Loss

Another benefit of Ipamorelin increasing metabolism is that it burns up body fat [4, 7]. It’s like stoking your body’s fire—the bigger the fire, the more of your body fat will be consumed in it.

Keep in mind this is not a diet pill, and you will not just effortlessly lose fat. You still need to work out and exercise in order to see the weight loss benefits. However, when you exercise having taken Ipamorelin, you will burn more calories than you would if you exercised without it.

Youthful Appearance

Ipamorelin benefits include an improved, more youthful appearance. This especially occurs by way of making the skin look more smooth, even, and young. It also helps to create healthier nails [8].

Because of its ability to support the regeneration of tissues, lots of people use Ipamorelin as an anti-aging supplement [8]. It has been shown to remove aged appearance from the skin, including increasing collagen production and reducing fine lines and wrinkles [14].

Bone Growth

Ipamorelin also appears to induce bone growth, bone mineral density, and create stronger, healthier bones [1, 15]. This includes helping to support healthy joints.

Ipamorelin Dosing for Athletes

Ipamorelin is great for athletes who want to get to the top of their game because of its great physical benefits.

But be cautious if you’re a professional athlete. Ipamorelin is banned by a number of sports leagues, including Major League Baseball and the National Basketball Association. Some athletes have been banned or suspended for using and testing positive for Ipamorelin.


If you’re in athletics, make sure your league allows using Ipamorelin.

Ipamorelin Bodybuilding

Another thing to keep in mind: Ipamorelin bodybuilding effects may also differ from person to person.

Peptides affect everyone differently. Your body composition, medical conditions, and other factors will all play a role in your results. For instance, an athlete using Ipamorelin will likely see better results than someone who is not as active. Its effects for you may be different from its effects on other people.

Ipamorelin benefits are huge. But keep in mind that they are all really the benefits of HGH. All Ipamorelin really does is stimulate your body to produce more HGH naturally.

By stimulating more production Ipamorelin HGH levels increase and have a lot of really great effects. Here is a list of all the Ipamorelin benefits you can expect, backed up with research.

Ipamorelin Side Effects

Ipamorelin side effects are not severe; in general, it is considered safe to use. Still, there are a few side effects you should be aware of.

Some reported Ipamorelin side effects include:

  • Water retention in wrists or ankles

  • Headache

  • Pain, rash, or soreness at injection sites [16]

  • Lightheadedness

  • Transient fever

  • Insulin resistance [17]

  • Neoplasm

  • Hypertension [17]

  • Scoliosis

Because it can mess around with your blood sugar and blood pressure, people with diabetes or that suffer from high blood pressure should not take Ipamorelin except with instructions from a doctor.

 

In general, it should not be used by individuals under the age of 18 without approval by a doctor. When you’re young, your body already produces enough HGH, so you probably don’t need added Ipamorelin HGH anyways.


To avoid side-effects, choose a dosing level and cycle in concert with your doctor or health provider.

Ipamorelin Side Effects Notes

Some growth hormone releasing peptides, like GHRP-2 and GHRP-6 have the unwanted side effect of increasing hunger. Ipamorelin doesn’t cause an increase in appetite, which is one of the reasons that it is effective in helping people get rid of body fat and lose weight.

Also, it does not have an adverse effect on your body’s natural growth hormone production. Some substances, like synthetic HGH, can help you build muscle, but because you’re getting your HGH synthetically, your body shuts down its natural HGH production. So in the long run, it’s not good.


Ipamorelin does not have that side effect because it’s entire job is to increase natural HGH production from your body.


Also, since it is not a steroid, you also don’t have the side-effects of steroids. The use of Ipamorelin will not result in hair loss, acne, or changes in aggression like the use of steroids will.

Ipamorelin Dosage Guide

Ipamorelin, like other peptides, typically comes in powder form. You then reconstitute it with bacteriostatic water. You administer the drug by injecting it subcutaneously (under the skin) or intramuscularly (into a muscle) using a small insulin syringe. It’s best to move around the injection points to help your body recover.

If you are uncomfortable with injections, or unsure how to do them, consult your doctor or another medical professional.


Our recommendations are consistent with other recommendations in the field.

Recommended Ipamorelin dosage for bodybuilding:

  • Start with 100 micrograms (mcg) Ipamorelin dosage daily. Take it in the morning or evening.

  • Use in a cycle of 60 days. If you don’t see any effects, you can go up to 90 days.

  • Then take a month off before beginning another cycle. This will help avoid receptor desensitization and continually needing larger and larger doses.

  • Once you get used to it and can see the effect it has on your body, you may choose to build up to 200 to 300 mcg daily. But only increase Ipamorelin dosing level at the beginning of a new cycle.

You should always consult with your doctor before taking any medications. Your doctor may also suggest a dosing level that is appropriate for you.

Notes:
  • You can use a lower dose for weight loss or as an anti-aging product.

  • You can stack Ipamorelin with other growth hormone-releasing peptides.

  • Consistent timing of your dosing will help you keep your HGH levels stable throughout the day and maximize the results.

As with any substance or supplement, start with a relatively low Ipamorelin dosage and build up to a higher one after seeing what effect it has on your body.

Where to Buy Ipamorelin Online? | 2020 Guide

There are lots of places you can buy Ipamorelin online. But be careful. Ipamorelin, like a lot of other peptides, is not yet properly regulated, which means it’s a bit of a grey market out there and there’s a lack of regulation. A lot of companies are operating without a ton of rules.

So make sure you choose a supplier that you can trust.

We love Research Peptides because we know that they provide high quality peptides. They are a reputable company with a good record. Their products are very high-quality and research grade. They also offer a number of other benefits:

  • Quick shipping. Packages arrive within the US within 2-3 business days.

  • Convenient payment. They accept credit cards, but also cryptocurrency.
    Customer service.

  • They’re helpful and it’s easy to get in touch with a real person if you have a problem.

How to Order Ipamorelin in Your Country?

Peptide Sciences offers international shipping to anywhere in the world that is accessible by courier.

They charge $15 for shipping, but they waive charges if your order is over $200. Shipping internationally can take 7-10 days.

Ipamorelin vs. Sermorelin

What is the difference between Ipamorelin and Sermorelin? And which should you use?

Well, they both work by stimulating your body to release more HGH.


But they are different chemically. Ipamorelin is a synthetic substance that mimics growth hormone-releasing peptides (GHRPs). Sermorelin is a synthetic substance that mimics growth hormone-releasing hormones (GHRHs).


So Ipamorelin looks to your body like a peptide, whereas Sermorelin looks like a hormone. While Ipamorelin is a chain of 5 amino acids, Sermorelin is a chain of 29 amino acids.


Both work to increase growth hormone. One may work better for you than the other. Our advice: try both and see which has the results you are looking for.

Ipamorelin Review | Verdict

The verdict is…

Ipamorelin benefits can be significant. It can help you build lean muscle, lose fat, and repair other body tissue more quickly. There are also a number of other Ipamorelin benefits that you may see, such as younger-looking skin, healthy nails, and better sleep.


Keep in mind that, as with any substance, this isn’t a miracle cure for getting big muscles or losing weight. You still have to have a balanced diet and workout regularly or you will not see any muscle building or weight loss benefit.


What Ipamorelin will do is help your body have the hormones available that encourage it to build muscle quickly and effectively.


While it is generally considered to be safe, there are some Ipamorelin side effects, so make sure you’re aware of those. Most of them are not severe but they can be unpleasant. However, you should pay particular attention if you have diabetes or hypertension since it can affect your blood sugar and blood pressure. If you have one of those conditions, it’s not the right peptide for you.


Otherwise, you should be good to go — give it a shot.

Buy Ipamorelin from our #1 recommended vendor...

References

  1. Jiménez-Reina, L., Cañete, R., De la Torre, M. J., & Bernal, G. (2020). Chronic in vivo Ipamorelin treatment stimulates body weight gain and growth hormone (GH) release in vitro in young female rats. European Journal of Anatomy, 6(1), 37-45.

  2. Florini, J. R. (1987). Hormonal control of muscle growth. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 10(7), 577-598.

  3. Moyer, A. E., Rodin, J., Grilo, C. M., Cummings, N., Larson, L. M., & Rebuffé‐Scrive, M. (1994). Stress‐induced cortisol response and fat distribution in women. Obesity Research, 2(3), 255-262.

  4. Taaffe, D. R., Pruitt, L., Reim, J., Hintz, R. L., Butterfield, G., Hoffman, A. R., & Marcus, R. (1994). Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. The Journal of Clinical Endocrinology & Metabolism, 79(5), 1361-1366.

  5. Reddit (2020, May 16). Who can tell me more about GHRH (Ipamorelin). https://www.reddit.com/r/Peptides/comments/gkx8e9/who_can_tell_me_mo
    re_about_ghrh_Ipamorelin_the/

  6. Gobburu, J. V., Agersø, H., Jusko, W. J., & Ynddal, L. (1999). Pharmacokinetic-pharmacodynamic modeling of Ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharmaceutical Research, 16(9), 1412-1416.

  7. Thompson, J. L., Butterfield, G. E., Gylfadottir, U. K., Yesavage, J., Marcus, R., Hintz, R. L., … & Hoffman, A. R. (1998). Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women. The Journal of Clinical Endocrinology & Metabolism, 83(5), 1477-1484.

  8. Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

  9. Welle, S., Thornton, C. H. A. R. L. E. S., Statt, M. A. R. C. I. A., & McHenry, B. (1996). Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old. The Journal of Clinical Endocrinology & Metabolism, 81(9), 3239-3243.

  10. Cureton, K. J., Collins, M. A., Hill, D. W., & McElhannon, J. F. (1988). Muscle hypertrophy in men and women. Medicine and Science in Sports and Exercise, 20(4), 338-344.

  11. Erotokritou-Mulligan, I., Holt, R. I., & Sönksen, P. H. (2011). Growth hormone doping: A review. Open access journal of sports medicine, 2, 99.

  12. Ghigo, E., Arvat, E., Giordano, R., Broglio, F., Gianotti, L., Maccario, M., … & Deghenghi, R. (2001). Biologic activities of growth hormone secretagogues in humans. Endocrine, 14(1), 87-93.

  13. Frieboes, R. M., Murck, H., Maier, P., Schier, T., Holsboer, F., & Steiger, A. (1995). Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology, 61(5), 584-589.

  14. Bartke, A. (2019). Growth hormone and aging: updated review. The World Journal of Men’s Health, 37(1), 19-30.

  15. Andersen, N. B., Malmlöf, K., Johansen, P. B., Andreassen, T. T., Ørtoft, G., & Oxlund, H. (2001). The growth hormone secretagogue Ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth Hormone & IGF Research, 11(5), 266-272.

  16. Souza, F. M., & Collett-Solberg, P. F. (2011). Adverse effects of growth hormone replacement therapy in children. Arquivos Brasileiros De Endocrinologia & Metabologia, 55(8), 559-565.

  17. Honeyman, T. W., Goodman, M. H., & Fray, J. C. (1983). The effects of growth hormone on blood pressure and renin secretion in hypophysectomized rats. Endocrinology, 112(5), 1613-1617.

References

  1. Jiménez-Reina, L., Cañete, R., De la Torre, M. J., & Bernal, G. (2020). Chronic in vivo Ipamorelin treatment stimulates body weight gain and growth hormone (GH) release in vitro in young female rats. European Journal of Anatomy, 6(1), 37-45.

     

  2. Florini, J. R. (1987). Hormonal control of muscle growth. Muscle & Nerve: Official Journal of the American Association of Electrodiagnostic Medicine, 10(7), 577-598.

     

  3. Moyer, A. E., Rodin, J., Grilo, C. M., Cummings, N., Larson, L. M., & Rebuffé‐Scrive, M. (1994). Stress‐induced cortisol response and fat distribution in women. Obesity Research, 2(3), 255-262.

     

  4. Taaffe, D. R., Pruitt, L., Reim, J., Hintz, R. L., Butterfield, G., Hoffman, A. R., & Marcus, R. (1994). Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. The Journal of Clinical Endocrinology & Metabolism, 79(5), 1361-1366.

     

  5. Reddit (2020, May 16). Who can tell me more about GHRH (Ipamorelin). https://www.reddit.co
    m/r/Peptides/comme
    nts/gkx8e9/who_can_
    tell_me_more_about_
    ghrh_Ipamorelin_the/

     

  6. Gobburu, J. V., Agersø, H., Jusko, W. J., & Ynddal, L. (1999). Pharmacokinetic-pharmacodynamic modeling of Ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharmaceutical Research, 16(9), 1412-1416.

     

  7. Thompson, J. L., Butterfield, G. E., Gylfadottir, U. K., Yesavage, J., Marcus, R., Hintz, R. L., … & Hoffman, A. R. (1998). Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women. The Journal of Clinical Endocrinology & Metabolism, 83(5), 1477-1484.

     

  8. Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.

     

  9. Welle, S., Thornton, C. H. A. R. L. E. S., Statt, M. A. R. C. I. A., & McHenry, B. (1996). Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old. The Journal of Clinical Endocrinology & Metabolism, 81(9), 3239-3243.

     

  10. Cureton, K. J., Collins, M. A., Hill, D. W., & McElhannon, J. F. (1988). Muscle hypertrophy in men and women. Medicine and Science in Sports and Exercise, 20(4), 338-344.

     

  11. Erotokritou-Mulligan, I., Holt, R. I., & Sönksen, P. H. (2011). Growth hormone doping: A review. Open access journal of sports medicine, 2, 99.

     

  12. Ghigo, E., Arvat, E., Giordano, R., Broglio, F., Gianotti, L., Maccario, M., … & Deghenghi, R. (2001). Biologic activities of growth hormone secretagogues in humans. Endocrine, 14(1), 87-93.

     

  13. Frieboes, R. M., Murck, H., Maier, P., Schier, T., Holsboer, F., & Steiger, A. (1995). Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology, 61(5), 584-589.

     

  14. Bartke, A. (2019). Growth hormone and aging: updated review. The World Journal of Men’s Health, 37(1), 19-30.

     

  15. Andersen, N. B., Malmlöf, K., Johansen, P. B., Andreassen, T. T., Ørtoft, G., & Oxlund, H. (2001). The growth hormone secretagogue Ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth Hormone & IGF Research, 11(5), 266-272.

     

  16. Souza, F. M., & Collett-Solberg, P. F. (2011). Adverse effects of growth hormone replacement therapy in children. Arquivos Brasileiros De Endocrinologia & Metabologia, 55(8), 559-565.

     

  17. Honeyman, T. W., Goodman, M. H., & Fray, J. C. (1983). The effects of growth hormone on blood pressure and renin secretion in hypophysectomized rats. Endocrinology, 112(5), 1613-1617.

Table of Contents

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