Tesamorelin vs. Ipamorelin | The #1 A-Z Guide

tesamorelin review

In a direct match-up of Tesamorelin vs. Ipamorelin, which of the two human growth releasing substances would win?

That’s the question for lots of bio-hackers and bodybuilders. We know that human growth hormone (HGH) has incredible effects, but that there are serious side effects if you take it directly. Instead, it’s much better—and safer—to take peptides that cause your body to produce more of its own HGH. 


That’s why there are several human growth hormone-releasing peptides on the market these days, including Tesamorelin and Ipamorelin. Both Tesamorelin and Ipamorelin help your body grow and repair by increasing your own, naturally produced HGH. 


But they’re slightly different from each other in how they work, their benefits, and their side effects.


This article will detail those differences and help you decide, between Ipamorelin vs. Tesamorelin, which one might be right for your research and “test subjects”.

Buy Ipamorelin from the #1 online Peptides vendor in the world: Peptides Sciences

Buy Ipamorelin from the #1 online Peptides vendor in the world: Peptides Sciences

P.S: This is not medical or legal advice. This is strictly for entertainment purposes. We are not doctors – nor lawyers. All information below is presented for use on “test subjects” only. Not for human consumption. Please read my disclaimer.

What are Research Peptides?

Peptides are one of the most promising areas of study for health [1]. They’re chains of amino acids—the same substance that make up proteins [2]. But they’re not as long as proteins. 

Our bodies naturally make many peptides, and they have a huge effect on how our body regulates itself. For example, many hormones are actually peptides.


Because they are so promising, many scientists are eager to do research on different kinds of peptides to figure out what amazing effects they can have on our bodies. There are currently almost 500 peptides that the FDA recognizes as having therapeutic value to treat various diseases, including [3]:

  • Bone disorders

  • Genetic disorders

  • Cancer

  • Infectious disease

  • Cardiovascular problems

  • Immune system

  • Respiratory disorders

  • Eye disorders

  • Neurodegenerative problems

  • Poor hormonal health

  • Bone disorders

Some of the most commonly used peptides are Ipamorelin, Sermorelin, and Tesamorelin.

Since there is lots of research on peptides, there are also several vendors that sell peptides to “scientists” to conduct studies on “test subjects”. You can buy peptides legally online for that purpose.

tesamorelin

What is Tesamorelin?

Tesamorelin is a synthetic research peptide that was created in the 1990s by a Canadian technology company [4]. It is made up of a chain of 44 amino acids [5]. 

Tesamorelin has been approved by the United States FDA for use by individuals that suffer from excess fat in their midsection as a result of taking HIV medications [5]. It’s currently sold under the brand name Egrifta.

Mechanism of Action

The chemical structure of Tesamorelin is almost identical to a hormone that your body naturally makes called “growth hormone-releasing hormone” or GHRH. This hormone is part of your body’s mechanisms to regulate HGH.
 

GHRH binds to receptors in the pituitary gland, which produces HGH. It causes the pituitary gland to produce even more HGH and release it. The result is that GHRH increases the concentration of HGH in the blood [6]. 

Tesamorelin, because it is so similar to GHRH, has exactly the same effect: it causes up-regulation of HGH. It is through increasing HGH that there are so many Tesamorelin benefits.

Benefits of Tesamorelin

HGH has been shown to have a bunch of effects on the human body like increasing muscle mass, decreasing fat, and improving skin. Many of these have also been found to result when “test subjects” are given Tesamorelin, too. 

Tesamorelin benefits that have been found in the research include:

  • Increased HGH in the body [7]

  • Increased muscle mass [8]

  • Increased fat burning (lipolysis) [4, 9]

  • Nerve regeneration [10]

  • Cognitive improvements [11, 12]
Ipamorelin

Benefits of Tesamorelin

Ipamorelin is a pentapeptide, which means it’s a chain of 5 amino acids—much smaller than Tesamorelin [13]. It is chemically very similar to the body’s own natural growth hormone-releasing peptide 1 (GHRP-1) [14]. 

Ipamorelin was originally developed by Novo Nordisk, a Danish pharmaceutical company. 

Mechanisms of Action

Like Tesamorelin, Ipamorelin is an HGH agonist. It binds to cells in the pituitary gland that prompts the release of additional HGH into the blood. This ultimately results in increased plasma HGH levels.
 

The other effect of Ipamorelin is to suppress somatostatin. Somatostatin is a hormone that inhibits the production of HGH. By reducing this HGH inhibitor, Ipamorelin indirectly increases the body’s ability to produce additional HGH. 


Ipamorelin is considered very selective, which means that it pretty much only up-regulates HGH, but not other hormones like cortisol. This is a good thing: it’s targeted only on the one effect.

Benefits of Ipamorelin

Similar to Tesamorelin, Ipamorelin benefits come as a direct result of increasing blood HGH levels. So, many of the benefits of the two peptides are the same. Ipamorelin benefits include:

  • Increased blood HGH levels [15, 16]

  • Increased lean muscle mass [16, 17]

  • Increased lipolysis and fat burning [16, 17]

  • Improved sleep and energy

  • Youthful appearance and healthier skin [18]

  • Improved recovery from workout and injuries [16, 19]

  • More energy and improved sleep [20, 21]
    Increased bone density [22]

Best Human Growth Hormone-Releasing Peptide

Great, so both Tesamorelin and Ipamorelin benefits are fantastic… but which one is better? In a faceoff between Tesamorelin vs. Ipamorelin, who would win?

It’s difficult to say which is “better” because they both lead to increased secretion and production of HGH in the body.


It’s true that the research finds that they have slightly different effects (which is why our list of the benefits of each of them is slightly different). But, that could just be because scientists have done different research on the two, so we know different things about each of them. 


For example, Tesamorelin may also improve your skin, we just don’t know because we don’t have any studies that have looked at that. Similarly, Ipamorelin may also help regenerate nerves, we just don’t have any studies on it.


So, it’s hard to say how much of the difference between the two is a real difference, and how much of it is simply a lack of research about their effects. 


All we can do is go off the research we have. Based on that:

  • Tesamorelin seems better for regenerating nerves, improving cognition, and improving cardiac tissue.

  • Ipamorelin seems better for improving skin, recovering from workouts, and bone growth.

  • They both seem to effectively build muscle and burn fat.

Again, though, until we have head-to-head randomized control trials, there isn’t really enough evidence to say one is clearly better than the other.

Until we have that research, your best bet is to simply try both on your “test subjects” and see which one leads to the best observable results. 


As a matter of fact, they may be best used together. Tesamorelin may be better at creating HGH, and Ipamorelin better at releasing it. Many people stack these two peptides to get the best of both worlds.

Ipamorelin

Differences between Tesamorelin and Ipamorelin

Structure

The differences between Ipamorelin vs. Tesamorelin are primarily chemical.

They are both peptides—long chains of amino acids. But Tesamorelin is much longer at 44 amino acids in length. In contrast, Ipamorelin is just 5 amino acids long.

Mechanism of action

That difference means that they have a slightly different mechanism of action. Tesamorelin is officially a growth hormone-releasing hormone (GHRH) and Ipamorelin is technically a growth hormone-releasing peptide (GHRP). They mimic slightly different chemicals in the body and bind to different receptors.

So while they have the same ultimate effect (increasing HGH), they do it in slightly different ways. 

Ipamorelin vs. Tesamorelin cost

They’re also a bit different in terms of cost.

How much does Ipamorelin cost? Ipamorelin costs about $50 for 5 mg, which is about 50 doses. $50 worth of Ipamorelin can last you about 10 weeks. A bit less if your doses are larger.


Tesamorelin costs about $70 for 5 mg, which is about 5 doses. $70 of Tesamorelin will last about 1 week. Less if your doses are larger. 

So Ipamorelin costs significantly less than Tesamorelin.

Recommended Dosing/Cycling

Your “test subjects” will notice Tesamorelin benefits with the following dosing schedule:
  • 1 subcutaneous injection of 1 to 2 milligrams (mg) Tesamorelin dosage daily

  • at the same time each day, ideally before bed

  • 5 days a week

  • cycle for 60 days, with one month off

For Ipamorelin dosage, “test subjects” can start with:

  • 100 micrograms (mcg) Ipamorelin dosage daily

  • either in the morning or evening,

  • cycle for 60 days, with one month off

If you want to stack them for your “test subjects”, try this:

  • 100 micrograms (mcg) Ipamorelin dosage daily

  • either in the morning or evening,

  • with 1 mg Tesamorelin dosage before bed

  • 5 days a week

  • Cycle for 60 days, with one month off

How to Order Research Peptides online

It’s easy and perfectly legal to buy peptides online for research purposes. But be careful: not every vendor is trustworthy. There are lots of firms sending out an impure product that doesn’t work—and can even be dangerous. 

So the one thing you want to do if you’re ordering research peptides is to make sure you get them from a trustworthy source. 


How do you determine who is a trustworthy seller of Tesamorelin vs. Ipamorelin? Look for:

  • A website disclaimer making the terms and conditions of the product clear.

  • A site that publishes certificates of analysis that show 100% purity.

  • Independent reviews of the vendor from third-party websites.

  • Secure payment methods and a good guarantee.

  • Ipamorelin and Tesamorelin costs that aren’t too high.

In our opinion, your best bet for buying research peptides online is Peptide Sciences. We’ve only had excellent experiences and we know that they have the highest-quality product. 

Benefits of Peptide Sciences include:

  • American-made peptides with publicly available certificates of analysis.

  • Convenient shipping options with very quick delivery.

  • Shipping to most countries in the world.

  • Secure payment options, including accepting cyber currencies like Bitcoin.

  • Great customer service with a strong product guarantee. 

Side effects and Safety Concerns

So these research peptides—both Tesamorelin and Ipamorelin—are effective at what they do. But are they safe? What are the Ipamorelin and Tesamorelin side effects?

Because these chemicals are so similar to your body’s own natural hormones, there are relatively few side effects. Both Tesamorelin and Ipamorelin are considered safe and well-tolerated by most people. They also have a much better safety profile than directly taking HGH. 


But as with anything, there are some adverse effects that you should be aware of. 

Tesamorelin side effects

The most common Tesamorelin side effects (noted in about 2.2% of the population [7], include:

  • sweating

  • redness, itching, pain, swelling, and irritation at the site of injection

  • diarrhea

  • muscle aches
The following are even less common but possible
  • muscle or joint pain

  • numbness, tingling, swelling in arms or legs

  • diarrhea with fever and dehydration

  • shortness of breath

  • neuropathies

  • congestive heart failure
Since it can also affect blood glucose levels, Tesamorelin is not great for people with diabetes. 

Ipamorelin side effects

The most common Ipamorelin side effects include:

  • Pain, rash, or soreness at injection sites [23]
  • Lightheadedness

  • Headache

  • Transient fever

  • Water retention in wrists or ankles

  • Insulin resistance [24]
  • Neoplasm

  • Hypertension [24]
  • Scoliosis

Again, because Ipamorelin can influence blood glucose levels, it’s not ideal for people with diabetes or blood sugar sensitivities.

Avoiding side effects

For “test subjects” new to these peptides, one way to avoid side effects is to make sure they start with a low dose. See how their body reacts before taking a full dose. 
Ipamorelin

Ipamorelin vs. Tesamorelin | Verdict

So Tesamorelin vs. Ipamorelin: in the end, which one is better?

Neither is the clear winner. Both of them are effective and can have important effects on the body of a “test subject”.

The research suggests that some of their effects are different: Tesamorelin may help improve nerve damage and cardiac tissue; Ipamorelin hasn’t been found to have those effects. Similarly, Ipamorelin has been found to improve skin and bone density, whereas Tesamorelin hasn’t. 


But we don’t know if those differences are because of real differences, or just a lack of research. 


If you want to maximize the benefits from peptides for your “test subjects”, your best bet may just be to try both of them and see which have the best effects. You may find that one gives fewer side effects or has better results. 


Trial and error are at the heart of peptide research, so consider using it for your “test subjects” as well. 

Buy Tesamorelin from our #1 recommended vendor...

References

  1. Marketwatch.com (2020). Peptides Emerging As A Reliable Source of Therapeutic Agents. 
  2. Food and Drug Administration (2020). Impact Story: Developing the Tools to Evaluate Complex Drug Products: Peptides. Retrieved March 28, 2020. fda.gov
  3. THPdb: A database of FDA approved therapeutic peptides and proteins. Retrieved March 27, 2020. webs.iiitd.edu.in
  4. Patel, A., Gandhi, H., & Upaganlawar, A. (2011). Tesamorelin: A hope for ART-induced lipodystrophy. Journal of Pharmacy And Bioallied Sciences, 3(2), 319.
  5. Food and Drug Administration (2010). Chemistry Reviews: Application 22-505. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022505Orig1s0
    00ChemR.pdf
  6. Ferdinandi, E. S., Brazeau, P., High, K., Procter, B., Fennell, S., & Dubreuil, P. (2007). Non‐clinical pharmacology and safety evaluation of TH9507, a human growth hormone‐releasing factor analog. Basic & Clinical Pharmacology & Toxicology, 100(1), 49-58.
  7. Falutz, J., Allas, S., Blot, K., Potvin, D., Kotler, D., Somero, M., … & Turner, R. (2007). Metabolic effects of a growth hormone–releasing factor in patients with HIV. New England Journal of Medicine, 357(23), 2359-2370.
  8. Adrian, S., Scherzinger, A., Sanyal, A., Lake, J. E., Falutz, J., Dubé, M. P., … & Brown, T. T. (2019). The growth hormone releasing hormone analogue, Tesamorelin, decreases muscle fat and increases muscle area in adults with HIV. The Journal of Frailty & Aging, 8(3), 154-159
  9. Canadian Agency for Drugs and Technologies in Health (2016). Clinical review report: Tesamorelin (Egrifta). https://www.ncbi.nlm.nih.gov/books/NBK539124/
  10. Tuffaha, S. H., Singh, P., Budihardjo, J. D., Means, K. R., Higgins, J. P., Shores, J. T., … & Brandacher, G. (2016). Therapeutic augmentation of the growth hormone axis to improve outcomes following peripheral nerve injury. Expert Opinion on Therapeutic Targets, 20(10), 1259-1265.
  11. Friedman, S. D., Baker, L. D., Borson, S., Jensen, J. E., Barsness, S. M., Craft, S., … & Vitiello, M. V. (2013). Growth Hormone–Releasing Hormone Effects on Brain γ-Aminobutyric Acid Levels in Mild Cognitive Impairment and Healthy Aging. JAMA Neurology, 70(7), 883-890.
  12. Zdravkovic, M., Søgaard, B., Ynddal, L., Christiansen, T., Agersø, H., Thomsen, M. S., … & Ilondo, M. M. (2000). The pharmacokinetics, pharmacodynamics, safety and tolerability of a single dose of NN703, a novel orally active growth hormone secretagogue in healthy male volunteers. Growth Hormone & IGF Research, 10(4), 193-198.
  13. Raun, K., Hansen, B. S., Johansen, N. L., Thogersen, H., Madsen, K., Ankersen, M., & Andersen, P. H. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552-561.
  14. Isidro, M. L., & Cordido, F. (2006). Growth hormone secretagogues. Combinatorial Chemistry & High Throughput Screening, 9(3), 175-180.
  15. Jiménez-Reina, L., Cañete, R., De la Torre, M. J., & Bernal, G. (2002). Chronic in vivo Ipamorelin treatment stimulates body weight gain and growth hormone (GH) release in vitro in young female rats. European Journal of Anatomy, 6(1), 37-45.
  16. Taaffe, D. R., Pruitt, L., Reim, J., Hintz, R. L., Butterfield, G., Hoffman, A. R., & Marcus, R. (1994). Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. The Journal of Clinical Endocrinology & Metabolism, 79(5), 1361-1366.
  17. Thompson, J. L., Butterfield, G. E., Gylfadottir, U. K., Yesavage, J., Marcus, R., Hintz, R. L., … & Hoffman, A. R. (1998). Effects of human growth hormone, insulin-like growth factor I, and diet and exercise on body composition of obese postmenopausal women. The Journal of Clinical Endocrinology & Metabolism, 83(5), 1477-1484.
  18. Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermato-endocrinology, 4(3), 308-319.
  19. Erotokritou-Mulligan, I., Holt, R. I., & Sönksen, P. H. (2011). Growth hormone doping: A review. Open Access Journal of Sports Medicine, 2, 99.
  20. Ghigo, E., Arvat, E., Giordano, R., Broglio, F., Gianotti, L., Maccario, M., … & Deghenghi, R. (2001). Biologic activities of growth hormone secretagogues in humans. Endocrine, 14(1), 87-93.
  21. Frieboes, R. M., Murck, H., Maier, P., Schier, T., Holsboer, F., & Steiger, A. (1995). Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology, 61(5), 584-589.
  22. Andersen, N. B., Malmlöf, K., Johansen, P. B., Andreassen, T. T., Ørtoft, G., & Oxlund, H. (2001). The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth Hormone & IGF Research, 11(5), 266-272.
  23. Souza, F. M., & Collett-Solberg, P. F. (2011). Adverse effects of growth hormone replacement therapy in children. Arquivos Brasileiros De Endocrinologia & Metabologia, 55(8), 559-565.
  24. Honeyman, T. W., Goodman, H. M., & Fray, J. C. (1983). The effects of growth hormone on blood pressure and renin secretion in hypophysectomized rats. Endocrinology, 112(5), 1613.

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